Titre :
|
"NRG-3": What's in this?
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Auteurs :
|
A. BATISSE ;
M. MARILLIER ;
C. CHEVALLIER ;
E. BOURGOGNE ;
M. GREGOIRE ;
O. LAPREVOTE ;
S. DJEZZAR
|
Année de publication :
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2017
|
Pagination :
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96-100
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Note générale :
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Toxicologie Analytique et Clinique Vol.29, n°1 (Février 2017) . - 96-100
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Langues:
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Anglais
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Mots-clés :
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SANTEPSY
ANALYSE CHIMIQUE
;
CAS CLINIQUE
;
CATHINONE
;
EFFET SECONDAIRE
;
TOXICOLOGIE
|
Résumé :
|
The supply of recreational drugs has changed in the early 2000s and users increasingly buy cathinones over the Internet. There is a potential for significant toxicity associated with their use. Cathinone named "NRG-3" seems to be the most popular in Parisian CEIP data: the adverse events related to use of NRG-3 from 2011 to 2015 are reported. We aim at determining the chemical composition of NRG-3 available over the Internet and whether products differ depending on retailers. Three powders labelled "NRG-3" were purchased on July 2012 from three different Internet sites, moreover one capsule and one powder labelled "NRG-3" was given by drug users. These were analysed by LC?MSMS to determine active ingredients. The cathinones class was detected, without active adulterant. A great inconsistency in the qualitative and quantitative composition of products bearing identical labelling "NRG-3" was shown. We found two different single components: methylene dioxypyrovalerone (MDPV) and alpha-pyrrolidinopentiophenone (alpha-PVP) with mixture preparations in (3/5) samples. alpha-PVP varied from 4 to 80% and MDPV varied from 0 to 70%. There was significant variation of the products contained in NRG-3. This variation could be of clinical significance as the NRG-3 can be associated with worrisome toxicity. Marked agitation with violent and unpredictable acts is reported with MDPV: this molecule has a higher ability to cross the blood brain barrier because the pyrrolidine ring confers a low polarity. Given the plethora of NPS, proper drug identification is core essential for harm reduction associated with empowered users through education.
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En ligne :
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https://go.openathens.net/redirector/ghu-paris.fr?url=http://www.sciencedirect.com/science/journal/23520078/29/1
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