Titre : | Pre-treatment lesional volume in older stroke patients treated with endovascular treatment |
Auteurs : | Gauthier Duloquin, Aut. ; Marc Ferrigno, Aut. ; Wagih Ben Hassen, Aut. ; Maéva Kyheng, Aut. ; Nicolas Bricout, Aut. ; Grégoire Boulouis, Aut. ; Pierre Seners, Aut. ; Julien Labreuche, Aut. ; Guillaume TURC, Aut. ; Olivier Naggara, Aut. ; Charlotte Cordonnier, Aut. ; Hilde Henon, Aut. ; Marco Pasi, Aut. |
Année de publication : | 2022 |
Note générale : | INTERNATIONAL JOURNAL OF STROKE, In Press, february 2022 |
Langues: | Anglais |
Mots-clés : |
SANTEPSY ACCIDENT VASCULAIRE CEREBRAL ; PERSONNE AGEE ; PREVENTION MEDICALE |
Résumé : | Background:Recent studies in the general stroke population treated with endovascular treatment (EVT) reported that higher pre-treatment lesional volumes were independently associated with poor neurological outcome and functional dependence after stroke. However, it has been not evaluated in older patients. Aim:We test the association between the pre-treatment lesional volume on diffusion-weighted magnetic resonance imaging and relevant outcome measures in older adults with stroke treated with EVT. Methods:We included consecutive older adults with stroke (⩾80 years old) treated with EVT in two academic comprehensive stroke centers. The association between pre-treatment lesional volume and relevant outcome measures (poor outcome (modified Rankin scale 4–6), 3-month mortality and symptomatic intracerebral hemorrhage (sICH)) was evaluated using univariate and multivariable models. Results:Five hundred seventy-nine patients were included (mean age: 85.6 ± 4.1, median lesional volume was 10 ml; interquartile range: 3–30 ml). Pre-treatment lesional volume was associated with poor functional outcome (adjusted odds ratio (aOR): 1.87, 95% confidence interval (CI): 1.60–2.20, for +1 logarithmic increase of lesional volume), 3-month mortality (aOR: 1.50, CI: 1.28–1.76), and sICH (aOR: 1.67, CI: 1.27–2.20). A threshold lesional volume >35 ml predicted 90% of patients with poor functional outcome and a cut-off >51 ml predicted 90% of patients dead at 3 months. Conclusions:Pre-treatment lesional volume might contribute, in association with other relevant clinical features, to the selection of older stroke patients who will benefit from EVT. [résumé d'éditeur] |
Notes de contenus : | Fig. ; Tabl. ; 26 réf. bibliogr. |
En ligne : | https://go.openathens.net/redirector/ghu-paris.fr?url=https://journals.sagepub.com/doi/10.1177/17474930211068657 |
Service de l'auteur du GHU : |
Neuro Sainte-Anne |