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Real world transcranial magnetic stimulation for major depression: A multisite, naturalistic, retrospective study

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Title:	Real world transcranial magnetic stimulation for major depression: A multisite, naturalistic, retrospective study
Authors:	Noomane Bouaziz, Author ; Charles LAIDI, Author ; Samuel Bulteau, Author ; Caroline Berjamin, Author ; Fanny Thomas, Author ; Virginie MOULIER, Author ; René Benadhira, Author ; David Szekely, Author ; Emmanuel Poulet, Author ; Filipe Galvao, Author ; Olivier Guillin, Author ; Marie-Carmen Castillo, Author ; Anne Sauvaget, Author ; Marion Plaze, Author ; Dominique Januel, Author ; Jérôme Brunelin, Author ; Maud ROTHARMEL, Author
In :	JOURNAL OF AFFECTIVE DISORDERS (326, 2023)
Article on page:	26-35
Languages:	English
Descriptors:	SANTEPSY DEPRESSION MAJEURE ; DEPRESSION RESISTANTE ; ENQUETE RETROSPECTIVE ; STIMULATION MAGNETIQUE TRANSCRANIENNE
Abstract:	Background : In 2008, the U.S. FDA approved rTMS as a treatment against medication-resistant depression. However, real-world rTMS outcomes remain understudied. This study investigates how rTMS for depression is delivered in routine clinical practice in France, and measures its effectiveness as well as its moderators. Methods : Five centers provided retrospective data on patients who were treated with rTMS for treatment-resistant depression from January 2015 to December 2020. Patients were assessed twice using a hetero-questionnaire, with baseline and immediate post-treatment assessments. We conducted univariate analyses to study which factors were significantly associated with rTMS effectiveness. We then included age, gender, and significant factors in a multivariate model. Results : We collected data from 435 patients with a mean age of 51.27 (14.91): 66 % were female, and 26 % suffered from bipolar depression. Stimulation was delivered using four different stimulation parameters: 1 Hz (7 % of the individuals), 10 Hz (43 %), 20 Hz (12 %), and 50 Hz (intermittent Theta Burst Stimulation, iTBS) (38 %). The mean improvement of depressive symptoms was 33 % (p
Contents note:	Fig. ; Tabl. ; 81 réf. bibliogr.
Link for e-copy:	https://go.openathens.net/redirector/ghu-paris.fr?url=https://www.sciencedirect.com/science/article/pii/S0165032723000861
Service de l'auteur du GHU :	Service Hospitalo-Universitaire (SHU)